Grey's Anatomy is an American medical drama television series that premiered on American Broadcasting Company (ABC) as a mid-season replacement on March 27, 2005, and is currently in its 12th season. The series focuses on the fictional lives of surgical interns and residents as they gradually evolve into seasoned doctors, while trying to maintain personal lives and relationships. The title is a play on the name Gray's Anatomy, an English-language human anatomy textbook originally written by Henry Gray. The show's premise originated with Shonda Rhimes, who serves as an executive producer, along with Betsy Beers, Mark Gordon, Krista Vernoff, Rob Corn, Mark Wilding, and Allan Heinberg. The series was created to be racially diverse, utilizing a color-blind casting technique. While the show is set in Seattle, it is primarily filmed in Los Angeles, California.

The series' protagonist is Dr. Meredith Grey (Ellen Pompeo), who originally is accepted into the residency program at the fictional Seattle Grace Hospital. Meredith is assigned to work under Dr. Miranda Bailey (Chandra Wilson), along with Dr. Cristina Yang (Sandra Oh), Dr. George O'Malley (T. R. Knight), Dr. Izzie Stevens (Katherine Heigl), and Dr. Alex Karev (Justin Chambers). Following O'Malley's death and Stevens' departure, the hospital's merger with Mercy West brings in Dr. Jackson Avery (Jesse Williams) and Dr. April Kepner (Sarah Drew), in the sixth season.

The surgical wing is primarily supervised by Dr. Richard Webber (James Pickens, Jr.), who is eventually replaced by Dr. Derek Shepherd (Patrick Dempsey), then, later, Dr. Owen Hunt (Kevin McKidd) and finally, Dr. Miranda Bailey. Dr. Arizona Robbins (Jessica Capshaw) is head of pediatric surgery, Hunt is head of trauma, and Dr. Callie Torres (Sara Ramirez) is head of orthopedics. Before his death, Dr. Shepherd was the head of neurosurgery. He was later replaced by his sister, Dr. Amelia Shepherd (Caterina Scorsone).

Dr. Preston Burke (Isaiah Washington) departs at the conclusion of the third season, after a failed relationship with Dr. Cristina Yang, and is replaced by Dr. Erica Hahn (Brooke Smith), who leaves the show during the fifth season, and later Dr. Teddy Altman (Kim Raver), who departs at the end of the eighth season. Introduced at the end of the first season is Dr. Addison Montgomery (Kate Walsh), who leaves the show at the end of the third season, in order to launch her own spin-off medical drama, Private Practice. Dr. Callie Torres (Sara Ramirez) and Dr. Mark Sloan (Eric Dane) also enter the show in the second season, while Mark Sloan dies in the premiere of the ninth season. Meredith's half-sister, Dr. Lexie Grey (Chyler Leigh), appears in season three and dies at the end of season eight. Dr. Arizona Robbins is given series-regular status at the beginning of the sixth season. In the ninth season, a new set of five recurring interns were introduced, with four – Dr. Josephine "Jo" Wilson (Camilla Luddington), Dr. Shane Ross (Gaius Charles), Dr. Stephanie Edwards (Jerrika Hinton) and Dr. Leah Murphy (Tessa Ferrer) – becoming series regulars in the tenth season.

Grey's Anatomy is one of the highest-rated dramas in the key 18–49 demographic. While the ratings have fallen over the past few seasons, it was once among the overall top 10 shows in the United States. Grey's Anatomy has been well received by critics. Considered an impact on culture, the series has received numerous awards, and has also been included in various critics' top ten lists. It is the recipient of the 2007 Golden Globe Award for Best Television Series — Drama, and multiple Emmy nominations, including two for Outstanding Drama Series. The show has produced several specials, as well as distributed all seasons to DVD, and released a collection of merchandise. In 2012, Grey's Anatomy was named the fifth-highest revenue earning show, in terms of advertising per half-hour.

On May 7, 2015, ABC renewed the series for a twelfth season which premiered on September 24, 2015.

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