Brother's Keeper is a story about two brothers of the same mother but different fathers, Kiu Tin-sang (Ruco Chan) and Lo Wai-son (Edwin Siu). Sang was born in Hong Kong, the son of Chow Yuk-mui (Louise Lee) and Kiu Sum (Lee Kwok Lun). Due to Kiu Sum refusing to marry Chow Yuk-mui, Yuk-mui decided to take Sang to Foshan, China to start anew. In Foshan, Yuk-mui got married with Lo Fu-shing (Lau Kong) and gave birth to Son a few years afterwards.

Not long after, the family of four decided to cross the border to start a new life in Hong Kong. The family of four eventually got separated with Sang ending up in Hong Kong, while Yuk-mui, Fu-shing, and Son ending up in Macau.

The two brothers lived very different lives in the course of the next 20 years. The very hardworking and ambitious Sang managed to graduate from college and became a police officer like his biological father, Kiu Sum. He has a girlfriend named Rachael Cheuk (Linda Chung) whom he is willing to do anything to fulfill her dreams of opening a fashion store. In order to achieve his goal, he seduces Favio (Ankie Beilke) and uses her in the process. In addition, Sang also has an ambiguous relationship with a triad member named Keung Yung (Louis Cheung) who later caused Sang to end up in jail.

Son, who is very simple-minded, only wants to live a peaceful and comfortable life in Macau. He is good friends with Yiu Man-ying (Krystal Tin) and Lung Fei (Louis Yuen). In order to avoid his abusive father (Fu-shing), Fu-shing works with his mother (Yuk-mui) at a restaurant. The lives of the two brothers, Sang and Son began to change after they meet up again. The two brothers in the series will go from 20 to 50 years old.

Brother's Keeper (Chinese: 巨輪; literally "big wheel") is a Hong Kong television epic drama serial produced by Amy Wong and TVB. It premiered on 23 September 2013 on TVB Jade in Hong Kong.

The serial, set between the years 1980 and 2013, depicts the moral life struggles of two half-brothers Kiu Tin-sang (Ruco Chan) and Lo Wai-son (Edwin Siu) during the late and post-colonial periods of Hong Kong and Macau. Historical events that were set against this era, including Hong Kong's 1980 Touch Base Policy, Macau's relaxed immigration laws of 1982, the 1991 goldsmith robberies, the transfer of sovereignty over Hong Kong and Macau to China in the late 1990s, the 1998 Hong Kong financial crisis, the 1999 Macanese triad wars, the 2003 Hong Kong SARS outbreak, and the 2008 Hong Kong financial recession, serves as some of the key plot vehicles that drive the changing fates of the brothers and their families.

Development for Brother's Keeper began in mid-2012. A teaser trailer was unveiled at TVB's 2013 Sales Presentation event, which was held on 8 November 2012. The trailer premiered on TVB Jade on 24 November 2012. The serial was also exhibited as one of eighteen TVB grand television drama productions at the 17th Hong Kong International Film & TV Market in March 2013.