A group of people find themselves trapped in the backwoods of West Virginia, fighting for their lives againt a group of vicious and horribly disfigured inbred cannibals.
While rafting in the Bluefish River area, four college kids are attacked by the mutant cannibal hillbilly Three Finger. Only the teenager Alex succeeds in escaping running through the woods. Meanwhile, a group of dangerous criminals are tranported from the West Virginia Grafton Penitentiary in a custody bus escorted by three security guards through the backwoods. When they park in a rest stop in a police station, Sheriff Carver is informed about the missing teenager. The bus driver heads to their destination with the guards and the prisoner but a tow truck driven by Three Finger hits the bus that falls off the road. They are attacked by Three Finger and the perilous Carlo Chavez dominates the guards and the other prisoner. When they accidentally meet Alex, the girl tells how sick and threatening Three Finger is; sooner the survivals discover that Alex is telling the truth.

A group of people trapped in remote mountain areas in West Virginia , but they do not know that they have entered the site of a savage , waiting for them only death , in order to survive they began a desperate battle .