Forty-something Cecilia (Zoe Tay), better known as Sissy to her friends, is a cheery and vivacious seamstress. Diligent and keenly devoted to her art, Sissy has earned a respectable reputation in the trade for her superb craftsmanship and exquisite style. Her second-storey tailor shop Sissy's Seamstress at the Textile Centre is modest yet distinctly in a class of its own.
　　Sissy is recognized as an exceptionally talented seamstress, not only in her community but also garnering clients from far and wide. Moreover, Sissy's candid, affable and attentive disposition also makes her extremely well-liked and popular.
　　Wai Mun (Kenny Ho), her husband of many years, is the captain of an acclaimed Chinese restaurant. Although somewhat discontented with life since his migration from Hong Kong to Singapore, he and Sissy are a loving couple and enjoy a blissful marriage. They have a 15-year-old son (Edwin Goh) and a nine-year-old daughter (Regene Lim) who has a very close relationship with Sissy and is a source of great cheer and comfort to her.
　　In a twist of fate, an unexpected occurrence befalls their seemingly mediocre and uneventful lives. One day, as Sissy feels a hard lump in her left breast. A gush of complex emotions overwhelms her...